External beam radiotherapy
We carry out studies to understand the mechanisms of long-term radiation-induced chromosomal damage, to determine the best way to deliver radiosensitizers to tumours, and to enhance radiotherapy toxicity through combinations with immunotherapies.
Example. Topoisomerase II alpha is a biomarker of radiation sensitivity in cancer cells
Topoisomerase II alpha is a protein found in every cell due to its role in separating DNA, which is crucial to enable DNA to replicate itself. In human leukemia cell lines, the level of topisomerase II alpha correlated with the sensitivity of cells (here HL60, MX1 and MX2) to radiation in terms of the number of chromosomal aberrations (in red boxes). From Terry et al 2009.